HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Cyclohexylpiperazine → 6-[p-(4-Cyclohexyl-1-piperazinyl)phenyl]-1,2-dihydro-2-oxonicotinonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Cyclohexylpiperazine | HCID 87298 | — |
| Reactant | 6-(4-Fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carbonitrile | HCID 2765203 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | 6-[p-(4-Cyclohexyl-1-piperazinyl)phenyl]-1,2-dihydro-2-oxonicotinonitrile | HCID 21404617 | — |
Reaction Steps
From 11.7 g. of 6-(p-fluorophenyl)-1,2-dihydro-2-oxonicotinonitrile and 18.4 g. of N-cyclohexylpiperazine in 150 ml. of dimethyl sulfoxide, there is obtained 6-[p-(4-cyclohexyl-1-piperazinyl)phenyl]-1,2-dihydro-2-oxonicotinonitrile; m.p. 306°-312° (dec.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03951982 |
| Source dataset | uspto-grants-1976_04 |
| ORD ID | ord-3d625b764b3049c18a4004d6c875346d |
| Source note | uspto-grants-1976_04 |