HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Benzylpiperazine → 6-[p-(4-Benzyl-1-piperazinyl)phenyl]-1,2-dihydro-2-oxonicotinonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Benzylpiperazine | HCID 75994 | — |
| Reactant | 6-(4-Fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carbonitrile | HCID 2765203 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | 6-[p-(4-Benzyl-1-piperazinyl)phenyl]-1,2-dihydro-2-oxonicotinonitrile | HCID 21404498 | — |
Reaction Steps
From 11.7 g. of 6-(p-fluorophenyl)-1,2-dihydro-2-oxonicotinonitrile and 19.1 g. of N-benzylpiperazine in 150 ml. of dimethyl sulfoxide, there is obtained 6-[p-(4-benzyl-1-piperazinyl)phenyl]-1,2-dihydro-2-oxonicotinonitrile; m.p. 275°-286° (dec.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03951982 |
| Source dataset | uspto-grants-1976_04 |
| ORD ID | ord-57bf352255704f5dbf69d71ee3cc3ec8 |
| Source note | uspto-grants-1976_04 |