反应详情

A mixture of 9.1 g. of 6-[p-(4-methyl-1-piperazinyl)phenyl]-1,2-dihydro-2-oxonicotinonitrile, 2.0 g. of potassium hydroxide, 5.0 ml. of iodomethane and 250 ml. of absolute ethanol is stirred and heated at reflux for 5 hours, then evaporated at reduced pressure. The residue is washed thoroughly with warm water, then dried, to give 6-[p-(4-methyl-1-piperazinyl)phenyl]-1,2-dihydro-1-methyl-2-oxonicotinonitrile as the remaining solid.

1. additionA mixture of 9.1 g
2. temperatureheated
3. temperatureat reflux for 5 hours
4. customevaporated at reduced pressure
5. washThe residue is washed thoroughly with warm water
6. customdried