Methyl iodide → HCID 21404613, compound

HRID 1605935Notes

Reaction equation

HRID 1605935 reaction equation
[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([C:8]2[CH:13]=[CH:12][C:11]([C:14]3[NH:15][C:16](=[O:22])[C:17](=[CH:20][CH:21]=3)[C:18]#[N:19])=[CH:10][CH:9]=2)[CH2:4][CH2:3]1.[OH-].[K+].I[CH3:26]>C(O)C>[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([C:8]2[CH:9]=[CH:10][C:11]([C:14]3[N:15]([CH3:26])[C:16](=[O:22])[C:17](=[CH:20][CH:21]=3)[C:18]#[N:19])=[CH:12][CH:13]=2)[CH2:4][CH2:3]1

Participants

5

Reactant 3

HCID 6328Methyl iodideHCID 14797Potassium HydroxideHCID 21404488HCID 21404488, compound

Product 1

HCID 21404613HCID 21404613, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 9.1 g. of 6-[p-(4-methyl-1-piperazinyl)phenyl]-1,2-dihydro-2-oxonicotinonitrile, 2.0 g. of potassium hydroxide, 5.0 ml. of iodomethane and 250 ml. of absolute ethanol is stirred and heated at reflux for 5 hours, then evaporated at reduced pressure. The residue is washed thoroughly with warm water, then dried, to give 6-[p-(4-methyl-1-piperazinyl)phenyl]-1,2-dihydro-1-methyl-2-oxonicotinonitrile as the remaining solid.

Workup

  1. additionA mixture of 9.1 g
  2. temperatureheated
  3. temperatureat reflux for 5 hours
  4. customevaporated at reduced pressure
  5. washThe residue is washed thoroughly with warm water
  6. customdried

Sources & evidence

ORD record
ord-d636cefa85a4465e90ee41720d58e1a8
Source dataset
uspto-grants-1976_04
Patent number
US03951982

Reaction notes

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