HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl chloroformate → 3-Carbethoxy-8-methyl-3,8-diazabicyclo[3.2.1]octane
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl chloroformate | HCID 10928 | — |
| Reactant | N,N-diethyl-8-methyl-3,8-diazabicyclo[3.2.1]octane-3-carboxamide | HCID 423352 | — |
| Reactant | 8-Methyl-3,8-diazabicyclo(3.2.1)octane dihydrochloride | HCID 22120189 | — |
| Product | 3-Carbethoxy-8-methyl-3,8-diazabicyclo[3.2.1]octane | HCID 423350 | 73% |
Reaction Steps
8-Methyl-3,8-diazabicyclo[3.2.1]octane dihydrochloride (2.5 g, 0.0126 mole), prepared as described in Example 1, was reacted with 1.51 ml (0.0189 mole) ethyl chloroformate according to the procedure described above for 3-(N,N-diethylcarbamyl)-8-methyl-3,8-diazabicyclo[3.2.1]octane in Example 1. A white monohydrochloride, melting point 200°-205° C, was obtained in 73% yield: 2.16 g.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03951980 |
| Source dataset | uspto-grants-1976_04 |
| ORD ID | ord-63b9733f09c8406cabd50b979f16d7b7 |
| Source note | uspto-grants-1976_04 |