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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1605963Generated: November 4, 2026

Diethyl (ethoxymethylene)malonate → HCID 86733250, compound

https://huagongshe.com/reaction/1605963

Reaction equation

Participants

RoleNameHCIDCharge
ReactantDiethyl (ethoxymethylene)malonateHCID 6871—
ReactantEthyl 2-Amino-5-methylthiophene-3-carboxylateHCID 4062885—
SolventEthanolHCID 702—
ProductHCID 86733250HCID 86733250—

Reaction Conditions

Temperature110 °C

Reaction Steps

A mixture of 3.7 parts of ethyl 2-amino-5-methylthiophene-3-carboxylate and 4.4 parts of diethyl ethoxymethylenemalonate is heated at 110°C for 1.5 hour. After cooling ethanol is added and the crystals are collected by filtration, whereby diethyl (3-ethoxycarbonyl-5-methylthienyl)aminomethylenemalonate is obtained as crystals. Recrystallization from ethanol gives pale yellow needles melting at 67°-68°C.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS03951989
Source datasetuspto-grants-1976_04
ORD IDord-6350bbc247374657b909d597ed6281f3
Source noteuspto-grants-1976_04