Dimethyl Sulfate → HCID 13217719, compound

Participants

Reaction Steps

To a solution of 0.274 part of 2-bromo-4-hydroxythieno[2,3-b]pyridine-5-carboxylic acid in 3 parts by volume of a 2N aqueous solution of potassium hydroxide is added 0.24 part by volume of dimethyl sulfate. Treatment of the mixture in the manner described in Example 20 gives 2-bromo-4,7-dihydro-7-methyl-4-oxothieno[2,3-b]pyridine-5-carboxylic acid as crystals. Recrystallization from dimethylformamide-water gives colorless needles melting at 288°-290°C.

Provenance & Evidence