Cyclopropylamine → HCID 21545725, compound

HRID 1605999Notes

Reaction equation

HRID 1605999 reaction equation
Cl[C:2]1[C:10](=[O:11])[C:9]2[N:8]([CH3:12])[N:7]=[CH:6][C:5]=2[C:4](=[O:13])[C:3]=1[N:14]([C:18](=[O:20])[CH3:19])[CH:15]1[CH2:17][CH2:16]1.[CH:21]1([NH2:24])[CH2:23][CH2:22]1>C(O)C>[CH:21]1([NH:24][C:2]2[C:10](=[O:11])[C:9]3[N:8]([CH3:12])[N:7]=[CH:6][C:5]=3[C:4](=[O:13])[C:3]=2[N:14]([C:18](=[O:20])[CH3:19])[CH:15]2[CH2:17][CH2:16]2)[CH2:23][CH2:22]1

Participants

4

Reactant 2

HCID 69828CyclopropylamineHCID 21545710HCID 21545710, compound

Product 1

HCID 21545725HCID 21545725, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

6-Chloro-5-(N-acetyl-N-cyclopropylamino)-1-methyl-1H-indazole-4,7 -dione (2 grams prepared as in Example III) and cyclopropylamine (2 grams) in ethanol (25 milliliters) were heated together under reflux for 10 minutes. The solvent was then removed under reduced pressure and the residual red oil purified by chromatography on alumina using methylene chloride as eluant to yield the desired product having a melting point of 75°-78° C.

Workup

  1. temperatureunder reflux for 10 minutes
  2. customThe solvent was then removed under reduced pressure
  3. customthe residual red oil purified by chromatography on alumina

Sources & evidence

ORD record
ord-9fa1f212df994760af70907601dffdd4
Source dataset
uspto-grants-1976_04
Patent number
US03952003

Reaction notes

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