Ethanol → HCID 21545728, compound

HRID 1606000Notes

Reaction equation

HRID 1606000 reaction equation
Cl[C:2]1[C:10](=[O:11])[C:9]2[N:8]([CH3:12])[N:7]=[CH:6][C:5]=2[C:4](=[O:13])[C:3]=1[N:14]([C:18](=[O:20])[CH3:19])[CH:15]([CH3:17])[CH3:16].C(N)(C)C.[CH2:25]([OH:27])[CH3:26]>>[CH2:25]([O:27][C:2]1[C:10](=[O:11])[C:9]2[N:8]([CH3:12])[N:7]=[CH:6][C:5]=2[C:4](=[O:13])[C:3]=1[N:14]([C:18](=[O:20])[CH3:19])[CH:15]([CH3:17])[CH3:16])[CH3:26]

Participants

4

Reactant 3

HCID 702EthanolHCID 6363IsopropylamineHCID 21545723HCID 21545723, compound

Product 1

HCID 21545728HCID 21545728, compound

Procedure

6-Chloro-5-(N-acetyl-N-isopropylamino)-1-methyl-1H-indazole-4,7-dione (3 grams prepared by a similar method to that described in Example III) and isopropylamine (3 grams) in ethanol (25 milliliters) were heated together under reflux for 10 minutes. On cooling the reaction mixture a yellow-orange solid crystallized out, which was filtered off and dried to yield 6-ethoxy-5-(N-acetyl-N-isopropylamino)-1-methyl-1H-indazole-4,7-dione having a melting point of 154°-155° C.

Workup

  1. temperaturewere heated together
  2. temperatureunder reflux for 10 minutes
  3. temperatureOn cooling the reaction mixture a yellow-orange solid
  4. customcrystallized out
  5. filtrationwhich was filtered off
  6. customdried

Sources & evidence

ORD record
ord-335ca8db72264387853cfd3a5be491b9
Source dataset
uspto-grants-1976_04
Patent number
US03952003

Reaction notes

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