Isopropylamine → HCID 21545713, compound

HRID 1606001Notes

Reaction equation

HRID 1606001 reaction equation
Cl[C:2]1[C:10](=[O:11])[C:9]2[N:8]([CH3:12])[N:7]=[CH:6][C:5]=2[C:4](=[O:13])[C:3]=1[N:14]([C:18](=[O:20])[CH3:19])[CH:15]([CH3:17])[CH3:16].[CH:21]([NH2:24])([CH3:23])[CH3:22]>C(Cl)Cl>[CH:21]([NH:24][C:2]1[C:10](=[O:11])[C:9]2[N:8]([CH3:12])[N:7]=[CH:6][C:5]=2[C:4](=[O:13])[C:3]=1[N:14]([C:18](=[O:20])[CH3:19])[CH:15]([CH3:17])[CH3:16])([CH3:23])[CH3:22]

Participants

4

Reactant 2

HCID 6363IsopropylamineHCID 21545723HCID 21545723, compound

Product 1

HCID 21545713HCID 21545713, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

6-Chloro-5-(N-acetyl-N-isopropylamino)-1-methyl-1H-indazole-4,-7-dione (3 grams) and isopropylamine (3 grams) in methylene chloride (25 milliliters) were heated under reflux for 15 minutes. The solvent was then removed under reduced pressure and the residue recrystallized from ethanol to give 6-isopropylamino-5-(N-acetyl-N-isopropylamino)-1-methyl-1H-indazole-4,7-dione as a red solid having a melting point of 123°-126° C.

Workup

  1. temperatureunder reflux for 15 minutes
  2. customThe solvent was then removed under reduced pressure
  3. customthe residue recrystallized from ethanol

Sources & evidence

ORD record
ord-8b7fe7126e0c4458bbaff3a5d8934045
Source dataset
uspto-grants-1976_04
Patent number
US03952003

Reaction notes

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