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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1606004Generated: October 25, 2026

Ethanol → 5,7-Dimethyl-1,2,3,7-tetrahydroimidazolo[1,2-a]pyridine-6,8-dicarboxylic acid diethyl ester

https://huagongshe.com/reaction/1606004

Reaction equation

Participants

RoleNameHCIDCharge
ReactantEthanolHCID 702—
ReactantEthyl (imidazolidin-2-ylidene)acetateHCID 12377942—
ReactantEthylideneacetoacetic acid ethyl esterHCID 53428592—
Product5,7-Dimethyl-1,2,3,7-tetrahydroimidazolo[1,2-a]pyridine-6,8-dicarboxylic acid diethyl esterHCID 1237795458%

Reaction Steps

Upon heating a solution of 6 g of ethylideneacetoacetic acid ethyl ester and 6 g of 2-carbethoxymethylideneimidazolidine in 50 ml of ethanol for 10 hours, 5,7-dimethyl-1,2,3,7-tetrahydroimidazolo[1,2-a]pyridine-6,8-dicarboxylic acid diethyl ester of melting point 138° (ethanol) is obtained.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS03951994
Source datasetuspto-grants-1976_04
ORD IDord-2b12af1b2bf24eefadd89099e2c59314
Source noteuspto-grants-1976_04