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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1606009Generated: October 29, 2026

2-Methylbenzylideneacetoacetic acid ethyl ester → 5-Methyl-7-(2-methylphenyl)-1,2,3,7-tetrahydroindolizine-6,8-dicarboxylic acid diethyl ester

https://huagongshe.com/reaction/1606009

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Methylbenzylideneacetoacetic acid ethyl esterHCID 54040073—
ReactantEthyl (pyrrolidin-2-ylidene)acetateHCID 68118984—
SolventEthanolHCID 702—
Product5-Methyl-7-(2-methylphenyl)-1,2,3,7-tetrahydroindolizine-6,8-dicarboxylic acid diethyl esterHCID 1237794362%

Reaction Steps

Upon boiling a solution of 7.7 g of 2-methylbenzylideneacetoacetic acid ethyl ester and 5.6 g of carbethoxymethylidenepyrrolidine in 50 ml of ethanol for 8 hours, 5-methyl-7-(2-methylphenyl)-1,2,3,7-tetrahydroindolizine-6,8-dicarboxylic acid diethyl ester of melting point 148° (alcohol) is obtained.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS03951994
Source datasetuspto-grants-1976_04
ORD IDord-b5f0c50d8d074618b5c6220646900719
Source noteuspto-grants-1976_04