Water → HCID 12562683, compound

Participants

Reaction Steps

5-Bromomethyl-3-(4-chlorophenyl)-1,2-benzisoxazole(6.5g.), sodium cyanide (1.1g) and dry sodium iodide (0.3g) were stirred together in dry dimethylformamide (50ml) for 20 hours at ambient temperature. The mixture was poured into water (500ml.), stirred for one hour and the brown solid filtered off, washed and dried (5.1g). This was recrystallised, with charcoaling, from 50% toluene/60-80 petrol ether (100ml.) To give the title compound as an off-white solid (3.4g) m.p. 118°C.

Provenance & Evidence