HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Ethylphenol → (4-Ethyl-2-hydroxyphenyl)(4-fluorophenyl)methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Ethylphenol | HCID 12101 | — |
| Reactant | 4-Fluorobenzoyl chloride | HCID 67879 | — |
| Product | (4-Ethyl-2-hydroxyphenyl)(4-fluorophenyl)methanone | HCID 12562657 | 5.3% |
Reaction Steps
3-Ethylphenol (24.4g) and 4-fluorobenzoyl chloride (34.9g) were reacted together as in Example 11 giving three main fractions: B (11.4g) 126°-129°C at 0.07 mmHg; C (7.9g), 129°-132°C at 0.06 mmHg; D (5.9g), 132°-150°C at 0.06 mmHg, all containing ~80% of the required isomer. B (4.0g) was separated by preparative thin layer chromatography to give the title compound (2.6g), m.p. 44°-48°C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03951999 |
| Source dataset | uspto-grants-1976_04 |
| ORD ID | ord-37bfe15f09714ba685a5c03749ea8082 |
| Source note | uspto-grants-1976_04 |