3,5-diphenyl-4,5-dihydro-1H-pyrazole → 1H-Pyrazole, 3,5-diphenyl-

HRID 1606037Notes

Reaction equation

HRID 1606037 reaction equation
[C:1]1([C:7]2[CH2:11][CH:10]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)[NH:9][N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1>[Pd]>[C:1]1([C:7]2[CH:11]=[C:10]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)[NH:9][N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

3

Reactant 1

HCID 36838443,5-diphenyl-4,5-dihydro-1H-pyrazole

Product 1

HCID 708401H-Pyrazole, 3,5-diphenyl-Yield 76.4%

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst2×

Procedure

The procedure of Example 18 is followed except that 2 parts of 5% palladium on barium sulfate are used in lieu of the palladium on alumina Example 18. Following a 2 1/2 hour of reflux, unreacted 3,5-diphenyl-2-pyrazoline is found to amount to 2.4%, and a 76.4% yield of 3,5-diphenylpyrazole, melting at 198° - 201°C. is obtained.

Workup

  1. customa 2 1/2 hour
  2. temperatureof reflux

Sources & evidence

ORD record
ord-9794ee26d89344e2a6c461f22e580921
Source dataset
uspto-grants-1976_04
Patent number
US03952010

Reaction notes

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