Sulfuric Acid → HCID 21545959, compound

HRID 1606099Notes

Reaction equation

HRID 1606099 reaction equation
[CH3:1]C1C=CC(/C(=C\C(O)=O)/C(O)=S)=CC=1.C(O[C:19]1[CH:20]=[C:21]2[C:26](=[CH:27][CH:28]=1)[S:25][C:24]([C:29]([O-:31])=[O:30])=[CH:23][C:22]2=[O:32])C.[Na+].S(=O)(=O)(O)O>>[CH3:1][C:19]1[CH:20]=[C:21]2[C:26](=[CH:27][CH:28]=1)[S:25][C:24]([C:29]([OH:31])=[O:30])=[CH:23][C:22]2=[O:32]

Participants

4

Reactant 3

HCID 1118Sulfuric AcidHCID 23673921HCID 23673921, compoundHCID 178425023HCID 178425023, compound

Product 1

HCID 21545959HCID 21545959, compound

Procedure

4.7 parts of 4-methylphenylthio fumaric acid, made in analogous manner to part (a) of Example 1, was added in small lots to 20 parts of stirred concentrated sulphuric acid. The solution was allowed to stand for 30 minutes and then it was cautiously poured on to ice. The resulting precipitate was filtered off, washed with water and crystallised from an ethanol/dioxan mixture to give 2.3 parts of 6-methyl-1-thiachromone-2-carboxylic acid, melting point 236°-7°C.

Workup

  1. additionwas added in small lots to 20 parts
  2. additionit was cautiously poured on to ice
  3. filtrationThe resulting precipitate was filtered off
  4. washwashed with water
  5. customcrystallised from an ethanol/dioxan mixture

Sources & evidence

ORD record
ord-0ab52fc459bb4af09c1ad1bfc3916ac0
Source dataset
uspto-grants-1976_04
Patent number
US03952013

Reaction notes

Loading…