2-Chloroethanol → HCID 21546011, compound

HRID 1606116Notes

Reaction equation

HRID 1606116 reaction equation
[Cl:1][CH2:2][CH2:3][OH:4].C1[C:8]2([CH2:23][O:22][CH2:21][CH2:20][O:19][CH2:18][CH2:17][NH:16][CH2:15][CH2:14][O:13][CH2:12][CH2:11][O:10][CH2:9]2)[CH2:7][O:6]1>>[OH:6][CH2:7][C:8]1([CH2:9][O:4][CH2:3][CH2:2][Cl:1])[CH2:23][O:22][CH2:21][CH2:20][O:19][CH2:18][CH2:17][NH:16][CH2:15][CH2:14][O:13][CH2:12][CH2:11][O:10]1

Participants

3

Reactant 2

HCID 342-ChloroethanolHCID 12212448HCID 12212448, compound

Product 1

HCID 21546011HCID 21546011, compound

Procedure

The oxetane ring in 2,6,9,15,18-pentaoxa-12-azaspiro[3.15]nonadecane was shown to add hydroxylic compounds by acid-catalyzed reaction with 2-chloroethanol to give 1-hydroxymethyl-1-(4-chloro-2-oxabutyl)-2,5,11,14-tetraoxa-8-azacyclopentadecane. ##EQU13##

Workup

  1. additionto add hydroxylic compounds

Sources & evidence

ORD record
ord-e5f8083fd3be44c18b8c6fb591684eb0
Source dataset
uspto-grants-1976_04
Patent number
US03952015

Reaction notes

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