Potassium Hydroxide → HCID 22750662, compound

Participants

Reaction Steps

13.5 g. of 1-methyl-5-(3-methylcarbethoxyaminopropyl)-5-hydroxy-5H-dibenzo[a,d]cycloheptene, 120 ml. of n-butanol and 14.5 g. of potassium hydroxide are boiled at reflux under an atmosphere of nitrogen for 20 hours. The solution is then evaporated to dryness and the residue taken up in ether. The ethereal solution is shaken out with dilute hydrochloric acid. The aqueous, acidic solution is again made alkaline with potassium carbonate. The oil which separates out is extracted with ether. The ethereal solution is washed with water, dried over sodium sulfate and evaporated. The 1-methyl-5-(3-methylaminopropyl)-5-hydroxy-5H-dibenzo[a,d]cycloheptene obtained is a thick oil which is immediately utilized as a reactant.

Provenance & Evidence