反应详情

A suspension of 2.42 g. (0.11 mole) of 5-benzoyl-1-methylpyrrole-2-acetonitrile, 0.9 g. (0.22 mole) sodium hydroxide, 6 ml. water, and 0.5 ml. ethanol, is stirred and refluxed for one hour. The resulting solution is cooled and extracted in water and chloroform. The aqueous fraction is made acidic with 3N hydrochloric acid. A white solid, 5-benzoyl-1-methylpyrrole-2-acetic acid, precipitates which is filtered and washed with a hexane-ether solution, m.p. 144°-145°C.

1. additionA suspension of 2.42 g
2. temperaturerefluxed for one hour
3. temperatureThe resulting solution is cooled
4. extractionextracted in water
5. customA white solid, 5-benzoyl-1-methylpyrrole-2-acetic acid, precipitates which
6. filtrationis filtered
7. washwashed with a hexane-ether solution, m.p. 144°-145°C.