Sodium Hydroxide → HCID 18424181, compound

HRID 1606144Notes

Reaction equation

HRID 1606144 reaction equation
[N+:1]([C:4]1[CH:23]=[CH:22][C:7]([C:8]([C:10]2[N:14]([CH3:15])[C:13]([CH2:16][C:17]([O:19]CC)=[O:18])=[CH:12][CH:11]=2)=[O:9])=[CH:6][CH:5]=1)([O-:3])=[O:2].[OH-].[Na+]>C(O)C>[N+:1]([C:4]1[CH:23]=[CH:22][C:7]([C:8]([C:10]2[N:14]([CH3:15])[C:13]([CH2:16][C:17]([OH:19])=[O:18])=[CH:12][CH:11]=2)=[O:9])=[CH:6][CH:5]=1)([O-:3])=[O:2]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 18424238HCID 18424238, compound

Product 1

HCID 18424181HCID 18424181, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 3.2 g. (0.01 mole) of ethyl 5-(p-nitrobenzoyl)-1-methylpyrrole-2-acetate and 25 ml. ethanol is brought to reflux. To this is added dropwise 10 ml. of 1N sodium hydroxide solution. After the addition is complete, the ethanol is evaporated and the residue is acidified with dilute hydrochloric acid. The resulting solid, 5-(p-nitrobenzoyl)-1-methylpyrrole-2-acetic acid, is separated by filtration and purified by recrystallization from ethanol, m.p. 192°-195°C.

Workup

  1. temperatureto reflux
  2. additionTo this is added dropwise 10 ml
  3. additionAfter the addition
  4. customthe ethanol is evaporated
  5. customThe resulting solid, 5-(p-nitrobenzoyl)-1-methylpyrrole-2-acetic acid, is separated by filtration
  6. custompurified by recrystallization from ethanol, m.p. 192°-195°C.

Sources & evidence

ORD record
ord-2e78c62202634e4489cdb02ca98f82bf
Source dataset
uspto-grants-1976_04
Patent number
US03952012

Reaction notes

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