HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 1,4-Dimethyl-5-(p-toluoyl)-pyrrole-2-acetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Ethyl 1,4 dimethyl-5-(rho-toluoyl)-pyrrole-2-acetate | HCID 18424313 | — |
| Solvent | Water | HCID 962 | — |
| Product | 1,4-Dimethyl-5-(p-toluoyl)-pyrrole-2-acetic acid | HCID 18544275 | — |
Reaction Steps
A suspension of 8.5 g. (0.0284 mole) of ethyl 1,4-dimethyl-5-(p-toluoyl)-pyrrole- 2-acetate in 29 ml. of 1N sodium hydroxide solution is heated under reflux for 20 min. The yellow solution is diluted with water and added to dilute hydrochloric acid. The precipitated solid is collected, dried in vacuo, and recrystallized from 2-propanol to give 1,4-dimethyl-5-(p-toluoyl)-pyrrole-2-acetic acid as a white solid, m.p. 160°-161°C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03952012 |
| Source dataset | uspto-grants-1976_04 |
| ORD ID | ord-b3aa18e7dcae4b2aa559557e4c15135d |
| Source note | uspto-grants-1976_04 |