3-Methylbutanal → HCID 54495141, compound

HRID 1606193Notes

Reaction equation

[CH3:1][C:2]1[N:3]=[CH:4][S:5][CH:6]=1.[Li].C([Li])CCC.[CH:13](=[O:18])[CH2:14][CH:15]([CH3:17])[CH3:16]>>[CH2:14]([CH:13]([C:4]1[S:5][CH:6]=[C:2]([CH3:1])[N:3]=1)[OH:18])[CH:15]([CH3:17])[CH3:16]

Participants

Reactant 4

HCID 115523-Methylbutanal

HCID 127484-Methylthiazole

HCID 3028194Lithium

HCID 178418339Butyllithium

Product 1

HCID 54495141HCID 54495141, compound

Procedure

Isobutyl (4-methyl-2-thiazolyl) carbinol was prepared by starting from 4-methyl-thiazole and substituting the hydrogen atom in the 2-position by lithium by reaction with butyl-lithium. The resulting metal-organic compound was reacted with isovaleraldehyde [cf. J.A.C.S. 74, 6260 (1952)]. The resulting product had a b.p. of 94°C./0.1 mm. Hg.

Sources & evidence

ORD record: ord-ed9cc9c53b674612bd14d29bbd3afca9
Source dataset: uspto-grants-1976_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US03952024

Reaction notes

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