Acetic Anhydride → S-(3,6-Dimethylpyrazin-2-yl) ethanethioate

HRID 1606200Notes

Reaction equation

[CH3:1][C:2]1[C:7]([SH:8])=[N:6][C:5]([CH3:9])=[CH:4][N:3]=1.CC1C2[O:18][CH:17]=[CH:16]C=2C=CC=1.C(OC(=O)C)(=O)C>>[CH3:1][C:2]1[C:7]([S:8][C:17](=[O:18])[CH3:16])=[N:6][C:5]([CH3:9])=[CH:4][N:3]=1

Participants

Reactant 3

HCID 7918Acetic Anhydride

HCID 331057-Methylbenzofuran

HCID 178430530HCID 178430530, compound

Product 1

HCID 20560338S-(3,6-Dimethylpyrazin-2-yl) ethanethioate

Procedure

2,5-Dimethyl-3-acetylthio-pyrazine was prepared by acetylating 2,5-dimethyl-3-mercapto-pyrazine [compound (2) a.] with acetic anhydride in an alkaline medium according to the method described in Houben-Weyl, 4th ed., vol. 9, 753 (1955). The product has a m.p. of 36°-42°C.

Sources & evidence

ORD record: ord-3e3e57b21c664c31beeccc238b667aba
Source dataset: uspto-grants-1976_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US03952024

Reaction notes

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