HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isocyanic acid → 2,5-Dimethyl-3,6-dipropylpyrazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isocyanic acid | HCID 6347 | — |
| Reactant | 2-Hexanone | HCID 11583 | — |
| Reactant | Nitrosyl chloride | HCID 17601 | — |
| Reactant | 3-Oximino-2-hexanone | HCID 71437750 | — |
| Catalyst | Zinc | HCID 23994 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 2,5-Dimethyl-3,6-dipropylpyrazine | HCID 596333 | — |
Reaction Steps
c. 2,5-Dimethyl-3,6-dipropyl-pyrazine was prepared by first forming 3-oximino-2-hexanone by reacting 2-hexanone with nitrosyl chloride according to the method of BOUVEAULT, Bull. [3] 31, 1163 (1904). The autocondensation of two molecules of the imino-ketone in the presence of zinc and acetic acid [according to the method described in Chimia 11, 310 (1957)] yielded 2,5-dimethyl-3,6-dipropyl-pyrazine which had a b.p. of 109°-110°C./10 mm. Hg.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03952026 |
| Source dataset | uspto-grants-1976_04 |
| ORD ID | ord-3ac6a8a1ebfd42e995c4edb1db1327a9 |
| Source note | uspto-grants-1976_04 |