HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isocyanic acid → 2,5-Bis(2-methylpropyl)-3,6-dimethylpyrazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isocyanic acid | HCID 6347 | — |
| Reactant | 5-Methyl-2-hexanone | HCID 8034 | — |
| Reactant | Nitrosyl chloride | HCID 17601 | — |
| Reactant | 5-Methyl-3-oximino-2-hexanone | HCID 71443027 | — |
| Catalyst | Zinc | HCID 23994 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 2,5-Bis(2-methylpropyl)-3,6-dimethylpyrazine | HCID 585410 | — |
Reaction Steps
f. 2,5-Diimethyl-3,6-diisobutyl-pyrazine was prepared by first forming 5-methyl-3-oximino-2-hexanone by reacting 5-methyl-2-hexanone with nitrosyl chloride according to the method of BOUVEAULT (loc.cit.). The autocondensation of two moles of the imino-ketone in the presence of zinc and acetic acid [according to the method described in Chimia 11, 310 (1957)] yielded 2,5-dimethyl-3,6-diisobutyl-pyrazine which had a b.p. of 69°-70°C./0.01 mm. Hg.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03952026 |
| Source dataset | uspto-grants-1976_04 |
| ORD ID | ord-474ff8dac471429e986350c83d00f249 |
| Source note | uspto-grants-1976_04 |