Triethyl phosphite → HCID 571485, compound

HRID 1606261Notes

Reaction equation

HRID 1606261 reaction equation
[C:1]([NH:4][C:5]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)(SC)[C:6]([O:8][CH3:9])=[O:7])(=[O:3])[CH3:2].P(OCC)(OCC)OCC>CO>[C:1]([NH:4][CH:5]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)[C:6]([O:8][CH3:9])=[O:7])(=[O:3])[CH3:2]

Participants

4

Reactant 2

HCID 31215Triethyl phosphiteHCID 24972452HCID 24972452, compound

Product 1

HCID 571485HCID 571485, compoundYield 65.5%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

145 Milligrams of methyl α-acetylamino-α-methylthiophenylacetate was dissolved in 10 ml of methanol. To the solution 0.15 ml of triethyl phosphite was added, and the system was refluxed for 4.5 hours. Following a reduced pressure concentration, the residue was parted by a column chromatography (Florisil and methylene chloride) to provide 78 mg of methyl α-acetylaminophenylacetate. The yield was 65.5%.

Workup

  1. temperaturethe system was refluxed for 4.5 hours
  2. concentrationa reduced pressure concentration

Sources & evidence

ORD record
ord-8c06ccf960b64c5daa11682853f0cbd6
Source dataset
uspto-grants-1976_04
Patent number
US03952044

Reaction notes

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