Methanol → HCID 68147389, compound

Participants

Reaction Steps

4.5 g. of rac.-1,3-dimethoxy-17β-acetoxy-8α-estra-1,3,5(10)-triene is saponified under N2 in 100 ml. of methanol with 13 ml. of aqueous potash solution (10%) by heating for 1.5 hours under reflux. After cooling, the mixture is gently neutralized with glacial acetic acid, concentrated to half its volume, precipitated into ice water/NaCl, and worked up, thus obtaining 4.1 g. of crude product. By recrystallization of 500 mg. from methanol, 330 mg. of final product is obtained, m.p. 153/153.5°-154°C.

Provenance & Evidence