Methanol → HCID 68148298, compound

Participants

Reaction Steps

A solution of 3 g. of 1,3-diacetoxy-8α-estra-1,3,5(10)-trien-17-one in 9 ml. of methylene chloride and 18 ml. of methanol is combined at 0° C. and under nitrogen with 0.23 ml. of perchloric acid (70%) in 1 ml. of methanol; the mixture is then agitated for 3 days at room temperature. Then, the mixture is diluted with ethyl acetate and washed neutral with saturated sodium chloride solution. After drying and evaporation, 2.9 g. of 1,3-dihydroxy-8α-estra-1,3,5(10)-trien-17-one is obtained as an oily substance.

Provenance & Evidence