反应详情

To 80 ml. of acetic anhydride stirred at 135°C. is added slowly 39.8 g. (0.185 mol) of the above N-oxide. The solution is stirred at this temperature for 30 minutes and then poured into 500 ml. of ice-water. After stirring the mixture for two hours it is extracted with a mixture of ethyl acetate and ether. The extract is washed with water, dried and evaporated to dryness. The residue is passed through an alumina column with ether as the eluent. Evaporation of the first fraction yields 2-acetoxymethyl-5-benzyloxypyridine as an oil.

1. additionis added slowly 39.8 g
2. additionpoured into 500 ml
3. stirringAfter stirring the mixture for two hours it
4. extractionis extracted with a mixture of ethyl acetate and ether
5. washThe extract is washed with water
6. customdried
7. customevaporated to dryness
8. customEvaporation of the first fraction