HCID 12397269, compound → HCID 12397272, compound

Participants

Reaction Steps

A solution of 600 mg. (2 mmol) of 5-benzyloxy-α-(N-t-butylaminomethyl)-2-pyridinemethanol (liberated from the hydrochloride salt) in 100 ml. of ethanol is hydrogenated over 600 mg. of 10% palladium-on-carbon at 50 psi for 10 minutes. The catalyst is filtered and ethanol evaporated to dryness. The residue is recrystallized from ethanol to give α-(t-butylaminomethyl)-5-hydroxy-2-pyridinemethanol, m.p. 163°-165°C.

Provenance & Evidence