Acetic Acid → HCID 86733285, compound

Participants

Reaction Steps

21-Bromo-3α-hydroxy-2β-methoxy-5α-pregnane-11,20-dione (600 mg.) was dissolved in dry acetone (15 ml.) and added to a mixture of glacial acetic acid (2 ml.) and triethylamine (3ml.) and refluxed for 41/2 hours. The mixture was diluted with chloroform, washed with water, dried and evaporated to a foam. Purification by preparative tlc followed by crystallisation from ethyl acetate and petrol gave the title compound (230 mg.) as colourless plates; m.p. 177°-180° [α]D + 112°.

Provenance & Evidence