Water → HCID 86733301, compound

Participants

Reaction Steps

2α,3α-Epoxy-5α-pregnane-11,20-dione (500 mg) was dissolved in propionic acid (10 ml) and the solution heated on a steam bath for 5 hours. The mixture was poured into water (200 ml) and the white precipitate extracted into ether. The ethereal solution was washed with 2N-sodium hydroxide solution until the aqueous layer remained basic, then water and then dried over anhydrous sodium sulphate. The dried solution was evaporated to a white foam (560 mg) which was purified by preparative T.L.C. using ethyl acetate/petrol (2/1). The main band (Rf 0.4-0.5) gave title compound (393 mg.) as a white foam. [α]D + 84.4° (c 1.05).

Provenance & Evidence