Sodium Iodide → HCID 86733304, compound

Participants

Reaction Steps

3α-Chloroacetoxy-2β-ethoxy-5α-pregnane- 11,20-dione (450 mg) was dissolved in acetone (50 ml) and sodium iodide (460 mg) added to the solution. The mixture was refluxed for one-half hour, a white precipitate forming. The precipitate was filtered off and the filtrate evaporated to a yellow foam which ws partitioned between ether and water. The ethereal solution was dried over anhydrous sodium sulphate and evaporated to give 2β-ethoxy-3α-iodoacetoxy-5α-pregnane-11,20 -dione (460 mg) as a pale yellow foam.

Provenance & Evidence