3,5-Dimethoxybenzaldehyde → HCID 3041205, compound

HRID 1606463Notes

Reaction equation

HRID 1606463 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:8]=[C:9]([O:11][CH3:12])[CH:10]=1)[CH:6]=O.[CH2:13]([C:15]1[O:16][CH2:17][C:18]([CH2:22]C)([CH2:20]C)[N:19]=1)[CH3:14]>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:6]=[C:13]([C:15]2[O:16][CH2:17][C:18]([CH3:22])([CH3:20])[N:19]=2)[CH3:14])[CH:8]=[C:9]([O:11][CH3:12])[CH:10]=1

Participants

3

Reactant 2

HCID 817473,5-DimethoxybenzaldehydeHCID 21543074HCID 21543074, compound

Product 1

HCID 3041205HCID 3041205, compound

Procedure

3,5-Dimethoxybenzaldehyde was reacted with 2,4,4-triethyl-2-oxazoline to produce 2-[2-(3,5-dimethoxyphenyl)-1-methylethenyl]-4,4-dimethyl-2-oxazoline (P-1641), b.p. 171°-173° at 0.25 mm. It was administered to mice to determine the acute oral toxicity and a trained observer studied the animals for tranquilizing activity. The oral LD0 was determined to be over 5 g/kg and the animals receiving it were observed to be highly tranquilized. The compound is administered orally to animals in need of tranquilizing in a dosage of from about 100 to about 1000 mg/kg.

Sources & evidence

ORD record
ord-9ceefd0ffb6740a2b72a00d7d98c159b
Source dataset
uspto-grants-1976_04
Patent number
US03953432

Reaction notes

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