Water → HCID 70632676, compound

HRID 1606472Notes

Reaction equation

HRID 1606472 reaction equation
[OH:1][C@@H:2]1[CH2:21][CH2:20][C@@:19]2([CH3:22])[C@@H:4]([CH2:5][CH2:6][C@@H:7]3[C:18]2=[CH:17][CH2:16][C@@:15]2([CH3:23])[C@H:8]3[CH2:9][CH2:10][C@@H:11]2[C:12](=[O:14])[CH3:13])[CH2:3]1.[C:24](OC(=O)C)(=[O:26])[CH3:25].O>N1C=CC=CC=1>[C:24]([O:1][C@@H:2]1[CH2:21][CH2:20][C@@:19]2([CH3:22])[C@@H:4]([CH2:5][CH2:6][C@@H:7]3[C:18]2=[CH:17][CH2:16][C@@:15]2([CH3:23])[C@H:8]3[CH2:9][CH2:10][C@@H:11]2[C:12](=[O:14])[CH3:13])[CH2:3]1)(=[O:26])[CH3:25]

Participants

5

Reactant 3

HCID 962WaterHCID 7918Acetic AnhydrideHCID 13940962HCID 13940962, compound

Product 1

HCID 70632676HCID 70632676, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

3α-Hydroxy-5α-pregn-9(11)-en-20-one (3.7 g.) was dissolved in pyridine (37 ml.) and acetic anhydride (18.5 ml.) added; the reaction was allowed to stand at room temperature for 66 hr. It was then poured into water (4 l.) and stored at 2° for 2 hr., the white solid was filtered off and dried to give the title compound (3.8 g.) m.p. 163°-165°.

Workup

  1. waitstored at 2° for 2 hr
  2. filtration, the white solid was filtered off
  3. customdried

Sources & evidence

ORD record
ord-b42df83bce6d44b981d128609cc2ac89
Source dataset
uspto-grants-1976_04
Patent number
US03953429

Reaction notes

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