Hydrochloric Acid → HCID 22789223, compound

Participants

Reaction Steps

3α-Acetoxy-9β,11β-epoxy-5α-pregnan-20-one (500 mg.) was dissolved in ether and the ether evaporated to leave a gummy residue. Hydrochloric acid (11.6N; 5ml.) was added and the reaction stirred for 4 min., it was then poured into aqueous sodium bicarbonate solution and the solid filtered off, washed with water and dried. Crystallisation from methyl acetate-petrol gave the title compound (250 mg.), m.p. 175°-179°. Recrystallisation from aqueous acetone gave a sample m.p. 177°-179°, [α]D + 97°.

Provenance & Evidence