Potassium Bicarbonate → HCID 86733326, compound

Participants

Reaction Steps

A solution of 3α-acetoxy-5α-pregn-1-ene-11,20-dione (7.9 g.) in dry methanol (225 mg.) was treated with potassium bicarbonate (8.5 g.), and the mixture was refluxed under nitrogen for 11/2 hr. The reaction mixture was concentrated in vacuo, then poured into water, and the product was extracted with methylene chloride. The extract was washed with water, dried (Na2SO4), and evaporated in vacuo. The residue (6.0 g.) was purified by preparative t.l.c. and crystallisation from methyl acetate/petroleum ether to give the title compound (1.64 g.), m.p. 119°-121°, [α]D + 56.8°.

Provenance & Evidence