Water → HCID 86733326, compound

Participants

Reaction Steps

A solution of crude 3α-acetoxy-5α-pregn-1-ene-11,20-dione (3.6 g.) in dry methanol (96 ml.) was treated with a solution of potassium hydroxide (650 mg.) in methanol (72 ml.), and the mixture stirred under nitrogen at room temperature for 2 hr. The reaction mixture was poured into water, and the product extracted with methylene chloride. The extract was washed with water, dried (MgSO4), and evaporated in vacuo. The residue (3.1 g.) was subjected to preparative t.l.c. The more polar product afforded the title compound (1.66 g.), with an RF identical on t.l.c. to that of the product of (a).

Provenance & Evidence