Acetic Acid → HCID 22212670, compound

Participants

Reaction Steps

A solution of 20,20-ethylenedioxy-3α-hydroxy-5α-pregnan-11-one (350 mg.) in mthanol (20 ml.) was treated with 25% aqueous acetic acid (2 ml.) at room temperature. After 18 hr. more 25 % aqueous acetic acid (2 ml.) was added and after a further 27 hr. the mixture was diluted with chloroform, washed with water, dried (Na2SO4) and evaporated to leave a white foam (300 mg.). Crystallisation from acetone and petroleum ether (b.p. 60°-80°) gave the title compound (160 mg.) as off-white rods; m.p. 152°-154°; [α]D + 79°.

Provenance & Evidence