O-Methylhydroxylamine → HCID 131710153, compound

Participants

Reaction Steps

Benzhydryl 7-(2-thienylacetamido)-3-chlorocarbonyl-2-cephem-4-carboxylate reacts with 1.1 equivalents of methoxyamine in tetrahydrofuran at -76° C. to give benzhydryl 7-(2-thienylacetamido)-3-methoxyaminocarbonyl-2-cephem-4-carboxylate. 4'-Methoxybenzyl 7-butyramido-3-methylcarbonyldioxycarbonyl-3-cephem-4-carboxylate reacts with 1.1 equivalents phenylhydroxylamine in methylene chloride at -76° C. to provide 4'-methoxybenzyl 7-butyramido-3-phenylhydroxaminocarbonyl-3-cephem-4-carboxylate.

Provenance & Evidence