Anisole trifluoroacetic acid → HCID 131710155, compound

HRID 1606518Notes

Reaction equation

HRID 1606518 reaction equation
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][C:7]([NH:9][CH:10]1[C:39](=[O:40])[N:12]2[C:13]([C:23]([O:25]C(C3C=CC=CC=3)C3C=CC=CC=3)=[O:24])=[C:14]([C:17]([O:19][CH2:20][CH2:21][CH3:22])=[O:18])[CH2:15][S:16][C@H:11]12)=[O:8].FC(F)(F)C(O)=O.C1(OC)C=CC=CC=1>>[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][C:7]([NH:9][CH:10]1[C:39](=[O:40])[N:12]2[C:13]([C:23]([OH:25])=[O:24])=[C:14]([C:17]([O:19][CH2:20][CH2:21][CH3:22])=[O:18])[CH2:15][S:16][C@H:11]12)=[O:8]

Participants

3

Reactant 2

HCID 66633105Anisole trifluoroacetic acidHCID 131710156HCID 131710156, compound

Product 1

HCID 131710155HCID 131710155, compound

Procedure

Benzhydryl 7-thienylacetamido- 3-(n-propoxycarbonyl)-3-cephem-4-carboxylate was deesterified (65%) with a trifluoroacetic acid-anisole mixture as described in Example 10 to give the title acid as a white solid. The product exhibited biological activity against both gram-positive and gram-negative organisms.

Sources & evidence

ORD record
ord-4189e0205b9b4ab7b4873ef5a0b67a60
Source dataset
uspto-grants-1976_04
Patent number
US03953436

Reaction notes

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