反应详情

2-Hydrazinoquinoline (5.0 grams) was placed in a 250-milliliter three-necked flask equipped with a mechanical stirrer and a reflux condenser. To the flask was added 100 milliliters of n-butanoic acid. The reaction mixture was allowed to reflux overnight. In the morning the reaction mixture was cooled and then made basic by the addition of sodium hydroxide. The desired 1-propyl-s-triazolo(4,3-a)quinoline product was extracted from this solution with methylene chloride and the methylene chloride subsequently stripped off. The product was recrystallized from ethanol, m.p., 158.5°-9.5°C.

1. customequipped with a mechanical stirrer and a reflux condenser
2. temperatureto reflux overnight
3. temperatureIn the morning the reaction mixture was cooled
4. extractionThe desired 1-propyl-s-triazolo(4,3-a)quinoline product was extracted from this solution with methylene chloride
5. customThe product was recrystallized from ethanol, m.p., 158.5°-9.5°C.