Sodium Hydroxide → HCID 4161205, compound

HRID 1606524Notes

Reaction equation

HRID 1606524 reaction equation
[NH:1]([C:3]1[CH:12]=[CH:11][C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[N:4]=1)[NH2:2].[OH-].[Na+]>C(O)(=O)CCC>[CH2:5]([C:10]1[N:4]2[C:5]3[C:10]([CH:11]=[CH:12][C:3]2=[N:1][N:2]=1)=[CH:9][CH:8]=[CH:7][CH:6]=3)[CH2:6][CH3:7]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 85111Quinoline, 2-hydrazinyl-

Product 1

HCID 4161205HCID 4161205, compound

Reagents, catalysts & solvents 1

HCID 264Butyric AcidSolvent

Procedure

2-Hydrazinoquinoline (5.0 grams) was placed in a 250-milliliter three-necked flask equipped with a mechanical stirrer and a reflux condenser. To the flask was added 100 milliliters of n-butanoic acid. The reaction mixture was allowed to reflux overnight. In the morning the reaction mixture was cooled and then made basic by the addition of sodium hydroxide. The desired 1-propyl-s-triazolo(4,3-a)quinoline product was extracted from this solution with methylene chloride and the methylene chloride subsequently stripped off. The product was recrystallized from ethanol, m.p., 158.5°-9.5°C.

Workup

  1. customequipped with a mechanical stirrer and a reflux condenser
  2. temperatureto reflux overnight
  3. temperatureIn the morning the reaction mixture was cooled
  4. extractionThe desired 1-propyl-s-triazolo(4,3-a)quinoline product was extracted from this solution with methylene chloride
  5. customThe product was recrystallized from ethanol, m.p., 158.5°-9.5°C.

Sources & evidence

ORD record
ord-edf6d946c66a4cfc995ccbb9f24b9826
Source dataset
uspto-grants-1976_04
Patent number
US03953457

Reaction notes

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