HCID 178418361, compound → HCID 178518873, compound

HRID 1606532Notes

Reaction equation

HRID 1606532 reaction equation
[C:1]1([OH:14])[N:5]2[C:6]3[C:11]([CH:12]=[CH:13][C:4]2=[N:3][N:2]=1)=[CH:10][CH:9]=[CH:8][CH:7]=3.[H][H]>[Pd].C(O)C>[C:1]1([OH:14])[N:5]2[C:6]3[C:11]([CH2:12][CH2:13][C:4]2=[N:3][N:2]=1)=[CH:10][CH:9]=[CH:8][CH:7]=3

Participants

5

Reactant 2

HCID 178418361HCID 178418361, compoundHCID 178518860HCID 178518860, compound

Product 1

HCID 178518873HCID 178518873, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

s-Triazolo(4,3-a)quinolin-1-ol (2.0 grams) was mixed with 125 milliliters of ethanol, and 1.0 gram of 5 percent palladium on carbon was added. The resulting mixture was hydrogenated at 50 psi hydrogen pressure and a temperature of 50°C., for 6 hours. The mixture was then filtered to remove catalyst, and the filtrate was evaporated to yield the desired 4,5-dihydro-s-triazolo(4,3-a)quinolin-1-ol product, m.p., 181°-2.5°C. Its identity was confirmed by NMR and by microanalysis.

Workup

  1. additionwas added
  2. filtrationThe mixture was then filtered
  3. customto remove catalyst
  4. customthe filtrate was evaporated

Sources & evidence

ORD record
ord-3b4e3d3f256343b5b4f8182319f4e8d6
Source dataset
uspto-grants-1976_04
Patent number
US03953457

Reaction notes

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