Sodium Hydroxide → HCID 21543647, compound

HRID 1606533Notes

Reaction equation

HRID 1606533 reaction equation
[NH:1]([C:3]1[CH:12]=[CH:11][C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[N:4]=1)[NH2:2].[CH2:13]([O:15][CH2:16][CH2:17][C:18](O)=O)[CH3:14].[OH-].[Na+]>>[CH2:13]([O:15][CH2:16][CH2:17][C:18]1[N:4]2[C:5]3[C:10]([CH:11]=[CH:12][C:3]2=[N:1][N:2]=1)=[CH:9][CH:8]=[CH:7][CH:6]=3)[CH3:14]

Participants

4

Reactant 3

HCID 14798Sodium HydroxideHCID 613513-Ethoxypropionic acidHCID 85111Quinoline, 2-hydrazinyl-

Product 1

HCID 21543647HCID 21543647, compound

Procedure

2-Hydrazinoquinoline (50.0 grams; about 0.3 mole) and 3-ethoxypropionic acid (100 grams; about 0.85 mole) were mixed and refluxed for eight hours. The reaction mixture was then allowed to cool and made basic with 50 percent sodium hydroxide. A precipitate, the desired 1-(2-ethoxyethyl)-s-triazolo(4,3-a)quinoline, formed. It was separated by filtration and recrystallized from ethanol, m.p., 93°C. The identity of the product was confirmed by NMR and by microanalysis.

Workup

  1. temperaturerefluxed for eight hours
  2. temperatureto cool

Sources & evidence

ORD record
ord-7a7916d64150409b90c391dcbba64a3e
Source dataset
uspto-grants-1976_04
Patent number
US03953457

Reaction notes

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