Methanol → 2,2,6,6-Tetramethyl-4-piperidone

HRID 1606534Notes

Reaction equation

HRID 1606534 reaction equation
[Cl-].[NH4+].[CH3:3][C:4]1[CH2:9][C:8]([CH3:11])([CH3:10])[NH:7][C:6]([CH3:13])([CH3:12])N=1.C[OH:15]>>[CH3:12][C:6]1([CH3:13])[NH:7][C:8]([CH3:11])([CH3:10])[CH2:9][C:4](=[O:15])[CH2:3]1

Participants

4

Reactant 3

HCID 887MethanolHCID 25517Ammonium ChlorideHCID 68396Pyrimidine, 1,2,5,6-tetrahydro-2,2,4,6,6-pentamethyl-

Product 1

HCID 132202,2,6,6-Tetramethyl-4-piperidone

Procedure

17.2 g of acetonine hydrate, 3 g of methanol and 0.5 g of ammonium chloride are heated to 60° C. After a reaction time of 12 hours, it is shown by a gas-chromatographical analysis that about 80% of the employed amount of acetonine has been reacted to form triacetoneamine, which is isolated by distillation.

Workup

  1. customAfter a reaction time of 12 hours, it
  2. customhas been reacted

Sources & evidence

ORD record
ord-cff0b685ba7c4c96828aa58a1f6b9b8c
Source dataset
uspto-grants-1976_04
Patent number
US03953459

Reaction notes

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