反应详情

6.2 g. of 4-butylamino-6-mercapto-2-methyl-5-nitropyridine-3-carboxylic acid, ethyl ester (0.02 Mol.) are dissolved in 25 ml. of acetic acid at reflux temperature with stirring. Zinc dust is added cautiously in small portions until the solvent is colorless. The inorganic precipitate is then filtered off, the solvent is removed and the residue is dissolved in 10 ml. of methanol. The product 5-amino-4-butylamino-6-mercapto-2-methylpyridine-3-carboxylic acid, ethyl ester precipitates after the addition of aqueous ammonia, yield 3.6 g. (64%), m.p. 103°-105° (ethyl acetate).

1. filtrationThe inorganic precipitate is then filtered off
2. customthe solvent is removed
3. dissolutionthe residue is dissolved in 10 ml
4. customThe product 5-amino-4-butylamino-6-mercapto-2-methylpyridine-3-carboxylic acid, ethyl ester precipitates
5. additionafter the addition of aqueous ammonia, yield 3.6 g