HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanol → HCID 178469259, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Sodium Sulfide | HCID 14804 | — |
| Reactant | 6-Chloro-4-[[3-(dimethylamino)propyl]amino]-2-methyl-5-nitropyridine-3-carboxylic acid ethyl ester | HCID 53717160 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 178469259 | HCID 178469259 | — |
Reaction Steps
34.5 g. of 4-[[3-(dimethylamino)propyl]amino]-6-chloro-2-methyl-5-nitropyridine-3-carboxylic acid, ethyl ester are dissolved in 100 ml. of ethanol. 15 g. of sodium sulfide in 10 ml. of water are added and the mixture is stirred without cooling for 1 hour. After this time, the precipitated 4-[[3-(dimethylamino)propyl]amino]-6-mercapto-2-methyl-5-nitropyridine-3-carboxylic acid, ethyl ester is filtered off and recrystallized from methanol, yield 18 g. (53%), m.p. 131°-132°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03953461 |
| Source dataset | uspto-grants-1976_04 |
| ORD ID | ord-46b50d976ae042f9a6e96f42efc24d34 |
| Source note | uspto-grants-1976_04 |