反应详情

A mixture of (3-trifluoromethylphenoxy) (4-chlorophenyl)acetonitrile (10.68 g.), sodium azide (2.40 g.), ammonium chloride (1.98 g.) and hexamethylphosphoramide (85 ml.) is stirred at 60°-63°C. overnight (19 hours). The reaction mixture is cooled, poured into one liter of ice water containing 25 ml. of concentrated hydrochloric acid and this solution is extracted with 5 × 100 ml. of ether. The ether extracts are combined, extracted with water and dried over sodium sulfate. The ether solution is filtered, the ether is evaporated in vacuo and the residue is crystallized by trituration with methylcyclohexane. Recrystallization from a butyl chloride and methylcyclohexane mixture (about 1 to 1) affords 5-[α-(3-trifluoromethylphenoxy)-4-chlorobenzyl]tetrazole, m.p. 124.5°-126.5°C.

1. temperatureThe reaction mixture is cooled
2. extractionof concentrated hydrochloric acid and this solution is extracted with 5 × 100 ml
3. extractionextracted with water
4. dry with materialdried over sodium sulfate
5. filtrationThe ether solution is filtered
6. customthe ether is evaporated in vacuo
7. customthe residue is crystallized by trituration with methylcyclohexane
8. customRecrystallization from a butyl chloride and methylcyclohexane mixture (about 1 to 1)