2-Morpholinoethylamine → HCID 21543975, compound

Participants

Reaction Steps

N-tert-butyl-3-(2-furfurylamino-4-chloro-5-methylsulfonylbenzoyloxy)crotonamide (4.00 g.; 0.0085 mole) and N-(2-aminoethyl)morpholine (2.21 g.; 0.017 mole) are added to acetonitrile (100 ml.). The resulting solution is stirred at room temperature for 24 hours. The acetonitrile is removed under reduced pressure, and the residue is triturated with butyl chloride to give N-(2-morpholinoethyl)-2-furfurylamino-4-chloro-5-methylsulfonylbenzamide which after drying yields 2.7 g. (72%), m.p. 127°-130° C. Several recrystallizations from butyl chloride yields product with m.p. 132°-134° C.

Provenance & Evidence