Acetic Acid → HCID 13066648, compound

Participants

Reaction Steps

An aqueous solution of 4 g of sodium hydroxide in 10 ml of water was added to a mixture of 5.3 g of methyl 2,5-bis(2'-acetoxybenzamido)-benzoate obtained in Example 3 and 100 ml of methanol. The resulting mixture was stirred at room temperature for 20 - 30 hours and then poured into 500 ml of water containing 10 ml of acetic acid to precipitate crystals. The crystals were recovered by filtration, washed with water and recrystallized from a mixture of dioxane and water to yield 3.5 g of 2,5-bis(salicylamido)-benzoic acid having a melting point between 280° - 283°C (decomposition).

Provenance & Evidence