Hydrochloric Acid → HCID 13066646, compound

Participants

Reaction Steps

A mixture of 6.64 g of methyl 2,4-diaminobenzoate, 11.5 ml of triethylamine and 50 ml of tetrahydrofuran was added dropwise to a solution of 17.4 g of 2-acetoxybenzoylchloride in 300 ml of tetrahydrofuran over 0.5 - 1 hour, while stirring at 5° - 10°C. The stirring was then continued at room temperature for 2 hours. The resulting reaction mixture was poured into 1.5 l of diluted hydrochloric acid to precipitate crystals. The crystals were recovered by filtration, washed with water, dried and recrystallized from ethyl acetate to yield 15 g of methyl 2,4-bis(2'-acetoxybenzamido)-benzoate having a melting point between 143° - 145°C.

Provenance & Evidence